Unrelated dancer George Hook (George Hook Lupino, 1820–1902) assumed the surname Lupino after working with members of the Lupino family.

He became famous in the role of Harlequin and married Rosina Sophia Proctor (1831–1908) and had 16 children, at least 10 of whom became professional dancers, two of them marrying into the family of Sara Lane, manager of the Britannia Theatre Hoxton.

Of George Hook Lupino's 16 children:

• George Lupino (1853–1932), performed in Drury Lane pantomimes of the 1890s, with Dan Leno and was the father of George Barry (Barry) Lupino (1884–1962), Mark Lupino (1889–1930) and Vaudeville performer, actor, and writer Stanley Lupino (1893–1942) (father of Ida)
• Arthur Lupino (1864–1908) Animal impersonator. First to play the role of the role of Nana in Peter Pan in 1904
• Harry Charles Lupino (1867–1925), married into the Lane family and was the father of Lupino Lane (Henry William George Lupino, 1892–1959) and Wallace Lupino (1898–1961).

Other members from this second line include Stanley Lupino (1893–1942), Peter Lupino (1912–1994), and Rita Lupino (1921-2016).

Living descendents of the Lupino family who maintain the family tradition include Sara Lupino Lane (granddaughter of Lupino Lane), patron of The Music Hall Guild of Great Britain and America, and Patricia Lupino-Thompson. Thompson, former principal of a dance school in Manchester, is now a Fellow, examiner, lecturer, technical committee member and director of the International Dance Teachers Association, and a dance adjudicator for the British Federation of Festivals.