Hossein Hamadani, also spelled Hamedani (1955 - 2015) (Persian: حسین همدانی‎‎), was an Iranian Revolutionary Guard commander who served in Syria as both an advisor to the Syrian government during the Syrian Civil War and as overseer for Quds Force operations in support of the Syrian government.

Hamadani first rose to prominence during the 1979 Kurdish rebellion in Iran and the Iran-Iraq War, where he helped suppress the Communist rebellion in Iranian Kurdistan. Mohammad Ali Jafari appointed him as Deputy Commander of the IRGC in 2005, and together they planned how to deal with any attempted "velvet revolution" in Iran. Hamadani subsequently helped to suppress the 2009 election protests in Iran. He had been head of the IRGC’s Rassoulollah Corps in charge of Greater Tehran from November 2009 until January 2014, and had been subject to international sanctions since 14 April 2011.

Hamadani had also released a biography entitled Brother, It's Duty.

Hamadani was killed by an alleged Islamic State attack in Aleppo, Syria on 7 October 2015.