Sheikha Hassa bint Mohammed bin Khalifa Al Nahyan(Arabic: الشيخة حـصـة بـنت محمـــد بن خليفة آل نهيــان‎) (died January 28, 2018) was the first wife of the founder and the first President of UAE, the late emir (ruler) of Abu Dhabi, Sheikh Zayed bin Sultan Al Nahyan.

She was the mother of the current president of UAE and emir of Abu Dhabi, Sheikh Khalifa II (born 1948). Her father was Sheikh Mohammed bin Khalifa Al Nahyan, who was a senior figure of the House of Al Nahyan, until his death in 1979.