Wolfram Wuttke (17 November 1961 – 1 March 2015) was a German footballer who played as a midfielder.

He made his Bundesliga debut in October 1979 for FC Schalke 04 in a 3–0 win against SV Werder Bremen. From 1981 to 1982, he played one and a half seasons for Borussia Mönchengladbach before returning to Schalke. In summer 1983, he moved toHamburger SV. Günther Netzer, then Hamburg's sporting director, called him one of the greatest German football talents of all times.

After several disputes, Ernst Happel, Hamburg's manager, threw him out of the team in September 1985. After that, he played nearly four seasons for 1. FC Kaiserslautern. His good performance during that time earned him four caps in the national team and he was part of West Germany's squad at the UEFA Euro 1988 and the West German team that won the bronze medal at the 1988 Summer Olympics. Kaiserslautern canceled his contract in 1990 due to "unprofessional behaviour" and so he joined RCD Espanyol. In 1992, he returned to the Bundesliga and played for 1. FC Saarbrücken but he had to end his career at the age of 31 due to a fracture of the shoulder.

On 1 March 2015, he died due to a multisystem organ failure cause by a liver cirrhosis.