Mafia boss Giancana married Angelina DeTolve, the daughter of immigrants from the Italian region of Basilicata, on September 23, 1933.

They had three daughters, Antoinette, Bonnie and Francine. His wife died in 1954, leaving him to raise his daughters. Giancana never remarried and was known as a good family man, despite frequent infidelities, and held his late wife in high regard and respect. All of the Giancana daughters have married at least once.

As of 1984, at least one daughter, Antoinette, had taken the "Giancana" name again.