Valerio Zanone (22 January 1936 – 7 January 2016) was an Italian politician, who was secretary and president of the Italian Liberal Party. He was also a senator of the Democratic Party. He has been mayor of Turin from 1990 to 1991.

Zanone was born in Turin.

He graduated in philosophy at the University of Turin. After entering the Italian Liberal Party (Partito Liberale Italiano, PLI), he was regional councillor in Piedmont, and then member of the Italian Chamber of Deputies from 1976 (being confirmed until 1994). In 1976 he was appointed as national secretary of PLI, and was later president of the same.

In 1985 Zanone was appointed a Minister of Ecology in the first Bettino Craxi cabinet, and later was Minister of Industry under Craxi's second tenure (1986–1987), and Minister of Defence in Giovanni Goria and Ciriaco De Mita cabinets (1987–1989). He was also mayor of Turin for a year and a half (1990–1991).

After the Tangentopoli scandal and the dissolution of PLI, he formed a centre-left movement in Piedmont (Unione Liberaldemocratica). Later he participated in the foundation of L'Ulivo coalition and adhered to the The Daisy centre party.