Maria Mikhailovna Manaseina, née Korkunova (Мария Михайловна Манасеина; 1841 – 17 March 1903), also known as Marie de Manacéïne, was a Russian woman physician who published a number of books on fatigue and sleep. In 1872, she is supposed to have delivered an experimental proof for the cell-free alcoholic fermentation.

Manaseina was a disciple of Professor Ivan Tarkhanov. In her monograph Sleep she observed that the brain is in an active state during sleep. She cited dreams as "evidence of an ongoing psychic life of sleep generated by the brain". An English translation appeared in 1897 as Sleep: Its Physiology, Pathology, Hygiene, and Psychology.

Manaseina's father was historian Mikhail Korkunov, and legal philosopher Nikolai Korkunov was her brother. Her second husband Vyacheslav Manassein was a well-known physiologist. After their separation Manassein married Fyodor Dostoyevsky's niece.