Lisa Otto (14 November 1919 - 20 September 2013) was a German operatic soprano, particularly associated with soubrette and light coloratura roles.

She was born in Dresden, the daughter of bass Karl Otto, she studied at the Musikhochschule of her native city of Dresden with Susanne Steinmetz-Prée. She made her debut in Beuthen, as Sophie in Der Rosenkavalier, in 1941, where she remained until 1944. She then sang in Nuremberg (1944-45), Dresden (1945-51), and joined the Berlin State Opera in 1951, where she was to remain for some 30 years.

She is best known for soubrette roles such as Blondchen, Susanna, Zerlina, Despina, and Papagena in Mozart's operas. Other notables roles included Marzelline, Annchen, Zerline, etc. She took part in the creation of Giselher Klebe's Alkmene and Hans Werner Henze's Der junge Lord.

She made guest appearances at the Vienna State Opera, the Salzburg Festival, La Scala in Milan, the Paris Opera, and the Glyndebourne Festival Opera.

She was married to Hughe Lackert. She died in Berlin, aged 93.