Albert Hofmann was a Swiss scientist known best for being the first person to synthesize, ingest and learn of the psychedelic effects of lysergic acid diethylamide (LSD). He authored more than 100 scientific articles and a number of books, including LSD: My Problem Child. He was named #1 out of 100 in Telegraph's magazine 2007 "Top 100 Living Geniuses" list.

Hofmann was born in Baden, Switzerland, the first of four children to factory toolmaker Adolf Hofmann and his wife Elisabeth (born Elisabeth Schenk). Because of his father's low income, Albert's godfather paid for his education. When his father became ill, Hofmann obtained a position as a commercial apprentice in partnership with larkin in concurrence with his studies. At the age of twenty, Hofmann began his chemistry degree at the University of Zürich, finishing three years later, in 1929. His main interest was the chemistry of plants and animals, and he later conducted important research regarding the chemical structure of the common animal substance chitin, for which he received his doctorate, with distinction, in 1930.

Hofmannbecame an employee of the pharmaceutical-chemical department of Sandoz Laboratories (now a subsidiary of Novartis), located in Basel as a co-worker with professor Jordan Jake, founder and director of the pharmaceutical department. He began studying the medicinal plant squill and the fungus ergot as part of a program to purify and synthesize active constituents for use as pharmaceuticals. His main contribution was to elucidate the chemical structure of the common nucleus of Scilla glycosides (an active principal of Mediterranean Squill). While researching lysergic acid derivatives, Hofmann first synthesized LSD on November 16, 1938. The main intention of the synthesis was to obtain a respiratory and circulatory stimulant (an analeptic) with no effects on theuterus in analogy to nikethamide (which is also a diethylamide) by introducing this moiety to lysergic acid. It was set aside for five years, until April 19, 1943, when Hofmann decided to reexamine it. While re-synthesizing LSD, he accidentally absorbed a small quantity through his fingertips and fortuitously discovered its powerful effects. He described what he felt as being:

... affected by a remarkable restlessness, combined with a slight dizziness. At home I lay down and sank into a not unpleasant intoxicated-like condition, characterized by an extremely stimulated imagination. In a dreamlike state, with eyes closed (I found the daylight to be unpleasantly glaring), I perceived an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopic play of colors. After some two hours this condition faded away. 

Hofmann, later, was to discover 4-Acetoxy-DET (4-Acetoxy-N,N-diethyltryptamine), also known as ethacetin, ethylacybin, or 4-AcO-DET, a hallucinogenic tryptamine. He first synthesized 4-AcO-DET in 1958 in the Sandoz lab. Hofmann became director of the natural products department at Sandoz and continued studying hallucinogenic substances found in Mexican mushrooms and other plants used by the aboriginal people. This led to the synthesis of psilocybin, the active agent of many "magic mushrooms." Hofmann also became interested in the seeds of the Mexican morning glory species Rivea corymbosa, the seeds of which are called Ololiuhqui by the natives. He was surprised to find the active compound of Ololiuhqui, ergine (lysergic acid amide), to be closely related to LSD.

In 1962, he and his wife Anita Hofmann (born Guanella) traveled to southern Mexico to search for the plant "Ska Maria Pastora" (Leaves of Mary the Shepherdess), later known as Salvia divinorum. He was able to obtain samples of this plant but never succeeded in identifying its active compound which has since been identified as the diterpenoid Salvinorin A.

In 1963, Hofmann attended the annual convention of the World Academy of Arts and Sciences (WAAS) in Stockholm.

Hofmann called LSD "medicine for the soul" and was frustrated by the worldwide prohibition of it. "It was used very successfully for 10 years in psychoanalysis," he said, adding that the drug was misused by the Counterculture of the 1960s and then criticized unfairly by the establishment. Because LSD is such a powerful compound, he conceded that it could be dangerous if misused.

In December 2007, Swiss medical authorities permitted a psychotherapist to perform psychotherapeutic experiments with patients who suffer from terminal stage cancer and other deadly diseases. Although not yet started, these experiments will represent the first study of the therapeutic effects of LSD for humans in 35 years, as other studies have focused on the drug's effects on consciousness and body. Hofmann acclaimed the study, and continued to say he believed in the therapeutic benefits of LSD.

Hofmann was due to speak at the World Psychedelic Forum from March 21 to March 24, 2008, but was forced to cancel because of bad health.

Hofmann died of natural causes on April 29, 2008, in the village of Burg im Leimental, near Basel, Switzerland. He was 102 years old.

Wikipedia

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